Quality of life in Parkinson's disease improved by apomorphine pump: the OPTIPUMP cohort study.
Identifieur interne : 000181 ( Main/Exploration ); précédent : 000180; suivant : 000182Quality of life in Parkinson's disease improved by apomorphine pump: the OPTIPUMP cohort study.
Auteurs : Sophie Drapier [France] ; Alexandre Eusebio [France] ; Bertrand Degos [France] ; Marc Vérin [France] ; Franck Durif [France] ; Jean Philippe Azulay [France] ; François Viallet [France] ; Tiphaine Rouaud [France] ; Caroline Moreau [France] ; Luc Defebvre [France] ; Valerie Fraix [France] ; Christine Tranchant [France] ; Karine Andre [France] ; Christine Brefel Courbon [France] ; Emmanuel Roze [France] ; David Devos [France]Source :
- Journal of neurology [ 1432-1459 ] ; 2016.
English descriptors
- mix :
Abstract
To report on OPTIPUMP, a cohort study, investigating the impact in real-life clinical settings of continuous subcutaneous apomorphine infusion (CSAI) on the quality of life (HRQoL) of patients with Parkinson's disease. OPTIPUMP was a prospective, open-label, observational cohort study involving 30 investigational sites in France. CSAI was proposed as part of routine clinical care to patients aged ≥18 years, in absence of dementia, with a PD diagnosis and based on the presence of motor fluctuations not controlled by oral treatments. The impact of APO-pump on quality of life was evaluated as the difference in PDQ-39 scores between the initiation treatment and the follow-up visit after 6 months' treatment. All adverse events were recorded. Hyper- and hypodopaminergic behavioral tolerance was assessed on the Ardouin Scale of Behavior in Parkinson's Disease. Between September 2011 and January 2013, we enrolled 142 patients: 42 patients were withdrawn due to pump removal (33), death (4), lost of follow-up (4), no available data (1). 100 completed the study. At 6 months, their HRQoL had significantly improved (p = 0.011), as had their total UPDRS score (p < 0.001). Regarding the safety profile, Ardouin scale scores indicated that their hyperdopaminergic behaviors had not increased. CSAI had a favorable impact on HRQoL, with benefits outweighing risks. The analysis of the withdrawn patients highlights the heterogeneity of the use of the pump having an impact on its efficacy and tolerability.
Url:
DOI: 10.1007/s00415-016-8106-3
PubMed: 27060084
Affiliations:
- France
- Alsace (région administrative), Auvergne (région administrative), Auvergne-Rhône-Alpes, Grand Est, Hauts-de-France, Midi-Pyrénées, Nord-Pas-de-Calais, Occitanie (région administrative), Pays de la Loire, Provence-Alpes-Côte d'Azur, Rhône-Alpes, Région Bretagne, Île-de-France
- Aix-En-Provence, Clermont-Ferrand, La Tronche, Lille, Nantes, Paris, Rennes, Strasbourg, Toulouse
- Université Lille 2, Université Lille Nord de France
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wicri:level="3"><nlm:affiliation>Department of Neurology, EA 4712, University Rennes 1, CHU Pontchaillou, 2 Henri Le Guilloux, 35000, Rennes, France. sophie.drapier@chu-rennes.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, EA 4712, University Rennes 1, CHU Pontchaillou, 2 Henri Le Guilloux, 35000, Rennes</wicri:regionArea><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Eusebio, Alexandre" sort="Eusebio, Alexandre" uniqKey="Eusebio A" first="Alexandre" last="Eusebio">Alexandre Eusebio</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology and Movement Disorders, APHM Timone University Hospital and Institut de Neurosciences de la Timone, AMU-CNRS UMR 7289, Marseilles, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology and Movement Disorders, APHM Timone University Hospital and Institut de Neurosciences de la Timone, AMU-CNRS UMR 7289, Marseilles</wicri:regionArea><wicri:noRegion>Marseilles</wicri:noRegion><wicri:noRegion>Marseilles</wicri:noRegion></affiliation></author><author><name sortKey="Degos, Bertrand" sort="Degos, Bertrand" uniqKey="Degos B" first="Bertrand" last="Degos">Bertrand Degos</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Centre Expert et Inter-Régional de Coordination de la Maladie de Parkinson, Hôpital de la Pitié-Salpêtrière, APHP, 47-83 boulevard de l'Hôpital, 75013, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, Centre Expert et Inter-Régional de Coordination de la Maladie de Parkinson, Hôpital de la Pitié-Salpêtrière, APHP, 47-83 boulevard de l'Hôpital, 75013, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Vérin">Marc Vérin</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, EA 4712, University Rennes 1, CHU Pontchaillou, 2 Henri Le Guilloux, 35000, Rennes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, EA 4712, University Rennes 1, CHU Pontchaillou, 2 Henri Le Guilloux, 35000, Rennes</wicri:regionArea><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Durif, Franck" sort="Durif, Franck" uniqKey="Durif F" first="Franck" last="Durif">Franck Durif</name><affiliation wicri:level="3"><nlm:affiliation>Department of Movement Disorders and Neurology, CHU Clermont-Ferrand, 58 rue Montalembert, 63003, Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Movement Disorders and Neurology, CHU Clermont-Ferrand, 58 rue Montalembert, 63003, Clermont-Ferrand</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Azulay, Jean Philippe" sort="Azulay, Jean Philippe" uniqKey="Azulay J" first="Jean Philippe" last="Azulay">Jean Philippe Azulay</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology and Movement Disorders, APHM Timone University Hospital and Institut de Neurosciences de la Timone, AMU-CNRS UMR 7289, Marseilles, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology and Movement Disorders, APHM Timone University Hospital and Institut de Neurosciences de la Timone, AMU-CNRS UMR 7289, Marseilles</wicri:regionArea><wicri:noRegion>Marseilles</wicri:noRegion><wicri:noRegion>Marseilles</wicri:noRegion></affiliation></author><author><name sortKey="Viallet, Francois" sort="Viallet, Francois" uniqKey="Viallet F" first="François" last="Viallet">François Viallet</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, University Hospital, Avenue des Tamaris, 13616, Aix-En-Provence, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, University Hospital, Avenue des Tamaris, 13616, Aix-En-Provence</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Aix-En-Provence</settlement></placeName></affiliation></author><author><name sortKey="Rouaud, Tiphaine" sort="Rouaud, Tiphaine" uniqKey="Rouaud T" first="Tiphaine" last="Rouaud">Tiphaine Rouaud</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, CHU Nantes, boulevard Jacques-Monod-Saint-Herblain, 44093, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, CHU Nantes, boulevard Jacques-Monod-Saint-Herblain, 44093, Nantes</wicri:regionArea><placeName><region type="region" nuts="2">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Moreau, Caroline" sort="Moreau, Caroline" uniqKey="Moreau C" first="Caroline" last="Moreau">Caroline Moreau</name><affiliation wicri:level="3"><nlm:affiliation>Department of Movement Disorders and Neurology, INSERM U1171, Lille University, CHU Lille, 2, avenue Oscar Lambret, 59037, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Movement Disorders and Neurology, INSERM U1171, Lille University, CHU Lille, 2, avenue Oscar Lambret, 59037, Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name><affiliation wicri:level="3"><nlm:affiliation>Department of Movement Disorders and Neurology, INSERM U1171, Lille University, CHU Lille, 2, avenue Oscar Lambret, 59037, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Movement Disorders and Neurology, INSERM U1171, Lille University, CHU Lille, 2, avenue Oscar Lambret, 59037, Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valerie" last="Fraix">Valerie Fraix</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry and Neurology, CHU Grenoble, Avenue Maquis du Grésivaudan, 38700, La Tronche, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Psychiatry and Neurology, CHU Grenoble, Avenue Maquis du Grésivaudan, 38700, La Tronche</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">La Tronche</settlement></placeName></affiliation></author><author><name sortKey="Tranchant, Christine" sort="Tranchant, Christine" uniqKey="Tranchant C" first="Christine" last="Tranchant">Christine Tranchant</name><affiliation wicri:level="3"><nlm:affiliation>Department of Movement Disorders and Neurology, CHU Strasbourg, 1 Place de L Hôpital, 67000, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Movement Disorders and Neurology, CHU Strasbourg, 1 Place de L Hôpital, 67000, Strasbourg</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Andre, Karine" sort="Andre, Karine" uniqKey="Andre K" first="Karine" last="Andre">Karine Andre</name><affiliation wicri:level="1"><nlm:affiliation>CLINACT Groupe, Sèvre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CLINACT Groupe, Sèvre</wicri:regionArea><wicri:noRegion>Sèvre</wicri:noRegion><wicri:noRegion>Sèvre</wicri:noRegion></affiliation></author><author><name sortKey="Courbon, Christine Brefel" sort="Courbon, Christine Brefel" uniqKey="Courbon C" first="Christine Brefel" last="Courbon">Christine Brefel Courbon</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Pharmacology and Neurosciences, UMR 825 Inserm, University Hospital Toulouse III, 31059, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Clinical Pharmacology and Neurosciences, UMR 825 Inserm, University Hospital Toulouse III, 31059, Toulouse</wicri:regionArea><placeName><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Roze, Emmanuel" sort="Roze, Emmanuel" uniqKey="Roze E" first="Emmanuel" last="Roze">Emmanuel Roze</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Assistance Publique Hôpitaux de Paris, Inserm, U 1127, CNRS, UMR 7225, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Sorbonne Universités, 47-83 boulevard de l'Hôpital, 75013, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, Assistance Publique Hôpitaux de Paris, Inserm, U 1127, CNRS, UMR 7225, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Sorbonne Universités, 47-83 boulevard de l'Hôpital, 75013, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Devos, David" sort="Devos, David" uniqKey="Devos D" first="David" last="Devos">David Devos</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Pharmacology, INSERM U1171, Lille University, CHU Lille, 2, avenue Oscar Lambret, 59037, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Medical Pharmacology, INSERM U1171, Lille University, CHU Lille, 2, avenue Oscar Lambret, 59037, Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author></analytic><series><title level="j">Journal of neurology</title><idno type="eISSN">1432-1459</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term> Neurology</term><term> Neuroradiology</term><term> Neurosciences</term><term> Parkinson’s disease</term><term> Quality of Life</term><term>Apomorphine pump</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To report on OPTIPUMP, a cohort study, investigating the impact in real-life clinical settings of continuous subcutaneous apomorphine infusion (CSAI) on the quality of life (HRQoL) of patients with Parkinson's disease. OPTIPUMP was a prospective, open-label, observational cohort study involving 30 investigational sites in France. CSAI was proposed as part of routine clinical care to patients aged ≥18 years, in absence of dementia, with a PD diagnosis and based on the presence of motor fluctuations not controlled by oral treatments. The impact of APO-pump on quality of life was evaluated as the difference in PDQ-39 scores between the initiation treatment and the follow-up visit after 6 months' treatment. All adverse events were recorded. Hyper- and hypodopaminergic behavioral tolerance was assessed on the Ardouin Scale of Behavior in Parkinson's Disease. Between September 2011 and January 2013, we enrolled 142 patients: 42 patients were withdrawn due to pump removal (33), death (4), lost of follow-up (4), no available data (1). 100 completed the study. At 6 months, their HRQoL had significantly improved (p = 0.011), as had their total UPDRS score (p < 0.001). Regarding the safety profile, Ardouin scale scores indicated that their hyperdopaminergic behaviors had not increased. CSAI had a favorable impact on HRQoL, with benefits outweighing risks. The analysis of the withdrawn patients highlights the heterogeneity of the use of the pump having an impact on its efficacy and tolerability.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Alsace (région administrative)</li><li>Auvergne (région administrative)</li><li>Auvergne-Rhône-Alpes</li><li>Grand Est</li><li>Hauts-de-France</li><li>Midi-Pyrénées</li><li>Nord-Pas-de-Calais</li><li>Occitanie (région administrative)</li><li>Pays de la Loire</li><li>Provence-Alpes-Côte d'Azur</li><li>Rhône-Alpes</li><li>Région Bretagne</li><li>Île-de-France</li></region><settlement><li>Aix-En-Provence</li><li>Clermont-Ferrand</li><li>La Tronche</li><li>Lille</li><li>Nantes</li><li>Paris</li><li>Rennes</li><li>Strasbourg</li><li>Toulouse</li></settlement><orgName><li>Université Lille 2</li><li>Université Lille Nord de France</li></orgName></list><tree><country name="France"><region name="Région Bretagne"><name sortKey="Drapier, Sophie" sort="Drapier, Sophie" uniqKey="Drapier S" first="Sophie" last="Drapier">Sophie Drapier</name></region><name sortKey="Andre, Karine" sort="Andre, Karine" uniqKey="Andre K" first="Karine" last="Andre">Karine Andre</name><name sortKey="Azulay, Jean Philippe" sort="Azulay, Jean Philippe" uniqKey="Azulay J" first="Jean Philippe" last="Azulay">Jean Philippe Azulay</name><name sortKey="Courbon, Christine Brefel" sort="Courbon, Christine Brefel" uniqKey="Courbon C" first="Christine Brefel" last="Courbon">Christine Brefel Courbon</name><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name><name sortKey="Degos, Bertrand" sort="Degos, Bertrand" uniqKey="Degos B" first="Bertrand" last="Degos">Bertrand Degos</name><name sortKey="Devos, David" sort="Devos, David" uniqKey="Devos D" first="David" last="Devos">David Devos</name><name sortKey="Durif, Franck" sort="Durif, Franck" uniqKey="Durif F" first="Franck" last="Durif">Franck Durif</name><name sortKey="Eusebio, Alexandre" sort="Eusebio, Alexandre" uniqKey="Eusebio A" first="Alexandre" last="Eusebio">Alexandre Eusebio</name><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valerie" last="Fraix">Valerie Fraix</name><name sortKey="Moreau, Caroline" sort="Moreau, Caroline" uniqKey="Moreau C" first="Caroline" last="Moreau">Caroline Moreau</name><name sortKey="Rouaud, Tiphaine" sort="Rouaud, Tiphaine" uniqKey="Rouaud T" first="Tiphaine" last="Rouaud">Tiphaine Rouaud</name><name sortKey="Roze, Emmanuel" sort="Roze, Emmanuel" uniqKey="Roze E" first="Emmanuel" last="Roze">Emmanuel Roze</name><name sortKey="Tranchant, Christine" sort="Tranchant, Christine" uniqKey="Tranchant C" first="Christine" last="Tranchant">Christine Tranchant</name><name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Vérin">Marc Vérin</name><name sortKey="Viallet, Francois" sort="Viallet, Francois" uniqKey="Viallet F" first="François" last="Viallet">François Viallet</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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